Unyvero Study
In this study, we investigate the sensitivity and specificity of the PCR-analysis* by comparing the results of the PCR-analysis with the results of the culture of synovial fluid and the results of the regular tissue cultures. We specifically investigate the negative predictive value of this test.
In 100 revision total knee arthroplasties and 100 revision total hip arthroplasties, which are not suspected of infection, joint fluid is removed peroperatively via a puncture. Additionally, regular tissue cultures are taken. Part of the punctate is cultured just like the regular tissue cultures. The remaining liquid is used for the PCR analysis. Within 4 hours, the PCR result indicates whether a micro-organism is present, and if so, what type of micro-organism it is.
*A multiplex Polymerase Chain Reaction (PCR) analysis is used to examine which micro-organisms DNA are present in the sample. In the case of a regular culture, it is examined which microorganisms will "grow".
Curetis provides us with research support for materials.
Curetis has no role in the design and conduct of the study, the collection, management, analysis and interpretation of the data, or the preparation and review of the manuscript.